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This Concept Map, created with IHMC CmapTools, has information related to: LAB 16 - SEROLOGY, PART 2 - INDIRECT SEROLOGIC TESTING, direct serologic testing description Used to identify unknown antigens (such as microorganisms). A preparation known antibodies, called antiserum, is used to identify an unknown antigen., serology definitions humoral immunity, serology definitions antigen, serology types indirect serologic testing, indirect serologic testing examples Serologic test for infectious mononucleosis, plasma definition The liquid fraction of the blood before clotting., indirect serologic testing examples The EIA (ELISA) test for HIV infection, qualitative test description Only detects the presence or absence of specific antibodies in the patient's serum and is often used for screening purposes., antigen definition A substance that reacts with antibody molecules and antigen receptors on lymphocytes., The FTA-ABS test for syphilis description A confirming test for syphilis. Detects antibodies made against Treponema pallidum.The patient's serum is mixed with known T. pallidum on a microscope slide. If the test is positive, the spirochetes will fluoresce when viewed with a fluorescent microscope., The EIA (ELISA) test for HIV infection description Detects antibodies against HIV. The patient's serum is mixed with various known HIV antigens in test wells. A positive test appears as a color change in the test well., indirect serologic testing examples Serologic test for systemic lupus erythematosis (SLE), large molecular weight proteins and polysaccharides examples microbial structures, microbial exotoxins, allergens, foreign tissues and cells, the body's own cells that the body fails to recognize as "normal self", serology definitions plasma, Diagnosis of COVID-19 infection by the detection of antibodies made against SARS-CoV-2 antigens description Most of these tests look for the presence of antibodies (often IgM made early during an infection, as well as IgG made later during an infection and for a longer duration) against the N (nuclear) antigen of SARS-CoV-2. There is a greater problem with false-positive and false-negative results compared to the tests that detect SARS-CoV-2 RNA but test results can be determined much more quickly. Antibody tests are not currently recommend as the sole basis for diagnosis of acute COVID-19 infection., indirect serologic testing description Used to detect antibodies being made against a specific antigen in the patient's serum. Antibodies in a person's serum being made by that individual against an antigen associated with a particular disease are detected using a known antigen., indirect serologic testing examples The RPR test for syphilis, indirect serologic testing general procedure A sample of the patient's serum is mixed with the known antigen for that suspected disease., serum definition The liquid fraction of the blood after clotting., indirect serologic testing examples The FTA-ABS test for syphilis
